East-West Routes
East-west routes are one- or two-digit even numbers, which increase from south to north. The extremes are I-4 in Florida and I-96 in Michigan.
North-South Routes
North-south routes are one- or two-digit odd numbers, which increase from west to east. The extremes are I-5 on the west coast and I-97 in Maryland. However, there is an I-99, but it doesn't count. (A certain Congressman *cough*clear throat*Bud Shuster* brought home some serious bacon. He got an interstate in his district and got to number it himself!)
Three-Digit Interstates
Ones that start with an even number are either beltways around a city or are freeways that go through the city. Examples: The I-494/694 Twin Cities Beltway; I-480 through downtown Omaha
Ones that start with an odd number are spurs off of the main interstate. Examples: I-394 in Minneapolis; I-380 in Iowa
A three-digit interstate always has the two-digit part of the main interstate it's a spur/loop of.
When deciding which odd or even digit to use, it appears that some states have a concrete policy; some don't. For example, in Colorado the first through-city routes were I-225 and I-270, and then I-470 was planned. However, if you look at Minnesota, I-494 and I-694 were used for the beltway, and then I-394 was the first spur. The spur off of I-35 is I-535. Some states seem to do it geographically, which the first digit being used increasing as you go across the state.
Major vs. Minor Routes
You can also tell if a one- or two-digit interstate is a more "main" interstate than another by its last digit. By "main", I mean interstates which are cross-country routes, vs. just being a regional route.
On north-south interstates, the major ones end with a 5.
Letter Suffix
Routes: There used to be a whole slew of Interstate routes that had a letter
suffix. This was usually done by taking the two digits of a parent route, and
using N, S, E, or W to denote the secondary route as branching off in a
northerly, southerly, easterly, or westerly direction, respectivily. For
example, I-76 between Denver and I-80 used to be I-80S. As I said, there used to
be a whole bunch of these, but AASHTO now seriously frowns on these, so almost
all of them have been renumbered something else. The ones that do remain are
I-35E/I-35W in both Dallas/Fort Worth and the Twin Cities.
Letter Prefix
Routes: These are used exclusivly in the Non-Continental US. Interstate highways
in Hawaii are I-H1, H2, and H3. Alaska has Interstate highways, but these are
purely legislative, and are not signed. They are I-A1, A2, A3, and A4. Puerto
Rico would be I-PRIx if it had Interstates. We've had some pretty spirited
discussions on misc.transport.road about what an oxymoron it is having an
Interstate highway in Hawaii, but as it was pointed out, being an Interstate
means more than going across state lines: There's the need for freeways to
certain standards, plus the 90% federal funding that comes with
Interstates.
For more on interstates, go to an online list of interstate highways. There is also Kurumi's list of three digit Interstates. Another good place to check out is AASHTO's Interstate Highway Sign Policy, from Richard C. Moeur's site.